Tag: PAD

“Spooky Action at a Distance”: The Most Comprehensive Review Yet of Physiologic Neuromodulation for Limb Preservation #ActAgainstAmputation #Neuromodulation #SpinalCordStimulation #CLTI @BurnsTrauma @KeckSchool_USC @ResearchatUSC @USC

Our new paper in Burns and Trauma presents the most comprehensive review yet of spooky action at a distance therapies for diabetic limb preservation — from spinal cord stimulation and splenic ultrasound to remote ischemic conditioning and tibial transport. Five modalities, three mechanistic pathways, one shared destination: tissue repair at a distance.

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Sunday Morning Wish Fulfilled: AI Meets Thermometry in Diabetic Foot Remission — A Scoping Review of 60 Studies #ActAgainstAmputation #AI #Thermography #DFU

A scoping review from Kanazawa University maps 60 studies on AI-powered thermography for diabetic foot detection — and reveals a critical gap: nearly half of all studies were tested only in controlled environments, not the real world where feet actually live.

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From Foot to Fatality: The #DiabeticFootAttack Is Real, and It’s Worse Than You Think @alpslimb #ActAgainstAmputation

A new single-center study from the Netherlands quantifies the devastating outcomes of the diabetic foot attack: only 48.5% wound closure, 46% major amputation by 12 months, 26% one-year mortality, and 12-month amputation-free survival of just 39.7%. Time is tissue.

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🩸 PET Scans Reveal Localized Hyper-Perfusion in Diabetic Foot Ulcers #ActAgainstAmputation

Understanding the Vascular Dynamics of DFU Healing and Pathology A recent study published in the Journal of Clinical Medicine by Christensen et al. (2025) utilized Oxygen-15 Labeled Water PET imaging to investigate resting skeletal muscle perfusion in patients with Type 2 Diabetes Mellitus (T2DM) and diabetic foot ulcers (DFUs), comparing them to healthy controls. This... Continue Reading →

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Inflammation, Lipids, and Limb Risk: New Clues from Two Cohorts #ActAgainstAmputation #PAD #VascularDisease #CLTI

Peripheral artery disease (PAD) is one of the most devastating complications of diabetes—contributing to ischemic pain, functional decline, and, in severe cases, amputation. Despite its prevalence, early detection remains elusive, and clinicians continue to search for simple, reliable markers of risk. A new multicohort study led by Wang and colleagues now shines a spotlight on... Continue Reading →

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A Call to Action — By Congressional District: From the Amputation Heat Map @American_Heart #Diabetes @ALPSlimb #CLTI #ActAgainstAmputation

Making limb preservation a national priority- one congressional district at a time Does your congressman or congresswoman know where you are on the amputation heat map? That’s not just a rhetorical question. It’s a matter of life and limb. The American Heart Association’s PAD Collaborative has unveiled a powerful tool: an interactive map showing non-traumatic lower extremity amputation... Continue Reading →

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Exploring the Prognostic Role of Toe Pressures in Diabetic Foot Ulcers with Medial Arterial Calcification #PAD #CLTI #Diagnostics #DiabeticFoot #ActAgainstAmputation

In the landscape of diabetic foot care, the presence of medial arterial calcification (MAC) adds a significant layer of complexity to the management of diabetic foot ulcers (DFUs). A recent study published in the Annals of Vascular Surgery sheds light on the prognostic value of toe pressure (TP) measurements in predicting outcomes for this challenging patient population.... Continue Reading →

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Exploring the Risks of SGLT2i vs. DPP-4i as Add-On Therapies in Diabetes Care #Amputation #PAD #CLTI #Stent #DiabetesCare

A new study published in Diabetes Care sheds light on the comparative risks of peripheral artery disease (PAD)-related surgical events—such as amputations, stent placements, or vascular surgeries—between two classes of diabetes medications: sodium-glucose cotransporter 2 inhibitors (SGLT2i) and dipeptidyl peptidase 4 inhibitors (DPP-4i). Conducted among U.S. veterans, this retrospective cohort study analyzed over 150,000 episodes of medication... Continue Reading →

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Evaluating the Reliability of Portable Toe Pressure PPG Measurement Devices: Insights from Helsinki

The ability to accurately assess lower limb arterial circulation is critical in vascular medicine. A new study by Laamanen et al., from Maarit Venermo's unit published online in Vascular, evaluates the reliability of a portable toe pressure (TP) photoplethysmography (PPG) device compared to a stationary laser Doppler flowmeter (LD). This investigation sheds light on whether an... Continue Reading →

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Innovative Periosteal Distraction Technique for Diabetic Foot Ulcer Treatment #ActAgainstAmputation #PeriostealDistraction #PAD #CLTI

Example of sliding plate under skin and periosteum. It is then slowly lifted using (in this case) an external screw A recent study published in the Chinese Journal of Tissue Engineering Research presents an innovative approach for treating diabetic foot ulcers through periosteal distraction. This technique, grounded in Ilizarov's tension-stress principle, promotes both osteogenesis and... Continue Reading →

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