CC398 Staph Aureus in Diabetic Foot Osteomyelitis: Cause for Concern?

First Report of the Predominance of CC398 Staphylococcus aureus Strains in Osteomyelitis Complicating Diabetic Foot Ulcers: a national French study – Senneville – Clinical Microbiology and Infection – Wiley Online Library:

This from our colleagues E. Senneville, the late JL Richard and others in Clin Microbiol and Infection.


Staphylococcus aureus is the most common pathogen cultured from diabetic foot infection including diabetic foot osteomyelitis (DFOM). This French multicenter study determined the genetic content of S. aureus isolated from 157 consecutively cases admitted in 12 diabetic foot centres between 2008 and 2011. We describe for the first time the emergence of the CC398 methicillin-susceptible S. aureus clone, the main clone in DFOM and its tropism for bone. This clone spreads to humans from animal source due to an intrinsic virulence. This adaptation of S. aureus isolates looks as a worrisome problem and should be carefully monitored.

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