Congratulations to our SALSAmigo Vijay Viswanathan and colleagues for this tantalizing study published in Gene. Perhaps we can now begin preliminary consideration for screening in broader populations?
Highlights
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IL-6 − 174 C allele confers protection against DFU.
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SDF-1 801 A allele confers protection against DFU.
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TNF-α − 308 A allele (but not − 238 SNP) confers genetic susceptibility to DFU.
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IL-6 − 174 and TNF-α − 308 (but not SDF-1 801) control their respective serum cytokine levels.
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These SNPs also influence FPG, PPG, HbA1c, HDL, VLDL, TGL, urea, creatinine, adiponectin and leptin levels.
