KPC-producing Klebsiella rectal colonization is a risk factor for death in people with diabetic foot infections

KPC-producing Klebsiella pneumoniae rectal colonization is a risk factor for mortality in patients with diabetic foot infections.

Disturbing and fascinating early work from colleagues in Pisa and our SALSAmigo, Ben Lipsky.

KPC = Kleb. pneumonia carbapenemase



To evaluate the relationship between KPC-Kp gut colonization and mortality in diabetic patients with foot infection (DFI) we performed a single-center, retrospective, matched case-control study. In the study period, we identified 21 DFI patients with KPC-Kp gut colonization and 21 controls. The 90 day mortality rate was significantly higher in gut colonized patients (47%) than the controls (4%) (p= 0.013). A multivariate analysis demonstrated that gut colonization with KPC-Kp was the only independent predictor of mortality (odds ratio [CI]= 13.33 [1.90, 272.80], p= 0.024). In patients with DFI, KPC-Kp gut colonization appears to be an important risk factor for mortality.

David G. Armstrong

Dedicated to amputation prevention, wound healing, diabetic foot, biotechnology and the intersection between medical devices and consumer electronics.

One comment

  • This is the kind of report that led the ISDF committee to ask me to speak about the coming “Post-Antibiotic Era” this Wednesday in The Hague.

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