Taking a Toll: Toll-Like Receptors Increase Inflammation and Decrease Wound Healing in Diabetes

Increased expression of endosomal members of toll-like receptor family abrogates wound healing in patients with type 2 diabetes mellitus. – PubMed – NCBI.

Here’s a terrific study from Singh, et al.

Key messages:

1. endosomal toll-like receptors(TLRs)impair wound healing because of their inflammatory and neurotoxic roles
2. the investigators analysed the expression of TLR7 and TLR9 in 84 type 2 diabetes mellitus (T2DM) wounds and 6 control wounds
3.  TLR9 and TLR7 were up-regulated in wounds of T2DM cases compared with the control wounds
4. expression of endosomal TLRs varied with wound grade, infection and gender of the cases
5. functionally truncated TLR9 was found in wounds of T2DM cases contrary to the controls