Important work from Das and coworkers from David Sinclair’s and Leonard Guarente’s world-class team. Perhaps a final common pathway exists to delaying sarcopenia, frailty and decline?
Delaying Decay? Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging @DavidASincair

sarcopenia, fragility and decline, when the endothelium hardens and the epithelia are compacted, the cellular proliferation decreases, the renewal of the dermal cells stops ,the brain gradually drops the vitality of organs, and, these organs falls into decline.Cell migration decreases…. It’s easy to observe in diabetes, since diabetes is aging to speed it up. The probable solution is also the control of the presence of immature keratin in the dermis. Who says better ?