Here are the most up-to-date data on the possible association (or not) of SGLT2 inhibitors to diabetes related lower extremity amputation

Conclusions: Overall, there was no consistent evidence of SGLT2i exposure and increased risk of amputation. The increased risk of amputation seen in the large, long-term Canagliflozin Cardiovascular Assessment Study (CANVAS) trial for canagliflozin, and select observational studies, merits continued exploration.
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