Current concepts underlying the pathophysiology of acute Charcot neuroarthropathy in the diabetic foot and ankle @WesternU #ActAgainstAmputation

A brief, compelling review from Yates and coworkers from Western University’s College of Podiatric Medicine

Current concepts underlying the pathophysiology of acute Charcot neuroarthropathy in the diabetic foot and ankle. To summarize:

  • There are far more numerous connections between bone metabolism and the inflammatory cycle than previously thought.
  • IL-17E, advanced glycation end-products, and monocyte differentiation patterns are promising new avenues in CNA research.
  • The expanding power of genomics analysis may have unearthed a genetic predisposition to developing acute CNA among patients with diabetic peripheral neuropathy.
  • Clinical trials investigating the use of novel pharmacologic treatments for ACN are underway.

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