Current concepts underlying the pathophysiology of acute Charcot neuroarthropathy in the diabetic foot and ankle @WesternU #ActAgainstAmputation

A brief, compelling review from Yates and coworkers from Western University’s College of Podiatric Medicine

Current concepts underlying the pathophysiology of acute Charcot neuroarthropathy in the diabetic foot and ankle. To summarize:

  • There are far more numerous connections between bone metabolism and the inflammatory cycle than previously thought.
  • IL-17E, advanced glycation end-products, and monocyte differentiation patterns are promising new avenues in CNA research.
  • The expanding power of genomics analysis may have unearthed a genetic predisposition to developing acute CNA among patients with diabetic peripheral neuropathy.
  • Clinical trials investigating the use of novel pharmacologic treatments for ACN are underway.

ACCEPTED MANUSCRIP

David G. Armstrong

Dedicated to amputation prevention, wound healing, diabetic foot, biotechnology and the intersection between medical devices and consumer electronics.

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