Current concepts underlying the pathophysiology of acute Charcot neuroarthropathy in the diabetic foot and ankle. To summarize:
- There are far more numerous connections between bone metabolism and the inflammatory cycle than previously thought.
- IL-17E, advanced glycation end-products, and monocyte differentiation patterns are promising new avenues in CNA research.
- The expanding power of genomics analysis may have unearthed a genetic predisposition to developing acute CNA among patients with diabetic peripheral neuropathy.
- Clinical trials investigating the use of novel pharmacologic treatments for ACN are underway.