Tag: theragnostics

The effect of inflammation management on pH, temperature, and bacterial burden #ActAgainstAmputation #WoundHealing

Important work from Derwin and coworkers in Zena Moore's group. The aim of this feasibility study was to investigate the impact of inflammation management on wound pH, temperature, and bacterial burden, using the principles of TIME and Wound Bed Preparation. A quantitative non-comparative, prospective, descriptive observational design. Following ethical approval, 26 participants with 27 wounds... Continue Reading →

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Molecular Pathophysiology of Chronic Wounds: Current State and Future Directions #Theragnostics #Diagnostics @CSHL @UnivMiami

A great perspective from Pastar and coworkers from our long-time friend Marjana Tomic-Canic's lab at University of Miami published in Cold Spring Harbor Perspectives in Biology. Molecular Pathophysiology of Chronic Wounds: Current State and Future Directions Venous leg ulcers, diabetic foot ulcers, and pressure ulcers are complex chronic wounds with multifactorial etiologies that are associated... Continue Reading →

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The Use of Point-of Care Bacterial Autofluorescence Imaging in the Management of Diabetic Foot Ulcers: A Pilot Randomized Controlled Trial #Diagnostics #Theragnostics

Important work from our SALSAmigos in Leeds. We see a slow and steady march toward companion diagnostics for our patients. Here we see fluorescence-guided debridement as an example of this. OBJECTIVE To estimate comparative healing rates and decision-making associated with the use of bacterial autofluorescence imaging in the management of diabetic foot ulcers (DFUs). RESEARCH... Continue Reading →

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Bacterial Protease Activity (BPA) may reduce Hospitalization, Improve Quality of LIfe: RCT #Theragnostics #Diagnostics #ActAgainstAmputation

This published in the Journal of Wound Care Effectiveness of testing hard-to-heal wounds for bacterial protease activity: a randomised clinical trial The rapid lateral flow test for BPA is easy to perform, provides actionable results at the point-of-care, and is a useful diagnostic tool to assist wound care clinicians in evidence-based treatment decisions

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Bioinformatic Analysis Reveals Hub Immune-Related Genes of Diabetic Foot Ulcers #ActAgainstAmputation

This from Rong and coworkers Summary Points: Diabetic foot ulcer (DFU) is a complex and devastating complication of diabetes mellitus that are usually stagnant in the inflammatory phase.However, oral wound healing, which is characterized by a rapid and scarless healing process, is regarded an ideal model of wound healing.Thus, we performed a comprehensive bioinformatics analysis... Continue Reading →

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Classification of Diabetic Foot Ulcers Using Class Knowledge Banks #ArtificialIntelligence #DeepLearning #DiabeticFoot #C2SHiP

Intriguing work from Xu and coworkers showing a continued march toward improvement in AI Models. As the input improves, output will follow! Abstract Diabetic foot ulcers (DFUs) are one of the most common complications of diabetes. Identifying the presence of infection and ischemia in DFU is important for ulcer examination and treatment planning. Recently, the... Continue Reading →

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A Clinical Study to Evaluate Autofluorescence Imaging of Diabetic Foot Ulcers Using a Novel Artificial Intelligence Enabled Noninvasive Device #ActAgainstAmputation #DiabeticFoot

A Clinical Study to Evaluate Autofluorescence Imaging of Diabetic Foot Ulcers Using a Novel Artificial Intelligence Enabled Noninvasive Device Great work from our long-time friend and colleague Vijay Viswanathan and coworkers pushing diagnostics and theragnostics forward. Fluorescence of Bacteria Diabetic foot ulcers, with worldwide prevalence ranging from 12%-25%, are an important cause of nontraumatic lower... Continue Reading →

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Rapid Detection of Pathogens in Wound Exudate via Nucleic Acid Lateral Flow Immunoassay

Excellent work in diagnostics and theragnostics from Brunauer and coworkers in the journal Biosensors. Rapid Detection of Pathogens in Wound Exudate via Nucleic Acid Lateral Flow Immunoassay Abstract: The rapid detection of pathogens in infected wounds can significantly improve the clinical outcome. Wound exudate, which can be collected in a non-invasive way, offers an attractive... Continue Reading →

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Diagnostic Accuracy of Point-of-Care Fluorescence Imaging for the Detection of Bacterial Burden in Wounds

This excellent work from Le and coworkers strongly suggests that using a point of care diagnostic device (Moleculight) can identify elevated bacterial load and influence medical decision making. Objective: High bacterial load contributes to chronicity of wounds and is diagnosed based on assessment of clinical signs and symptoms (CSS) of infection, but these characteristics are poor... Continue Reading →

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A microbial-load-guided debridement decision tree using bacterial fluorescence imaging #DiabeticFoot #ActAgainstAmputation

Strong concept from Cole and Coe. One can see the future of theragnostic-driven care in works like this. Use of a bacterial fluorescence imaging system to target wound debridement and accelerate healing: a pilot study Objective: Optimal wound-bed preparation consists of regular debridement to remove devitalised tissues, reduce bacterial load, and to establish an environment... Continue Reading →

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