Wound pH and Surface Temperature as a Predictive Biomarker of Healing in Diabetic Foot Ulcers #Diagnostic #Theragnostic #Thermometry #ActAgainstAmputation @ALPSLIMB

More supportive literature surround inflammation and wound pH

Wound pH and Surface Temperature as a Predictive Biomarker of Healing in Diabetic Foot Ulcers – Bhavani Prasad Mahindrakar, Aakansha Giri Goswami, Farhanul Huda, Manisha Naithani, Somprakas Basu, 2023
This graphic from another manuscript (Roychoudhury and coworkers) DOI:10.1149/2.0231808jes


To monitor wound pH and surface temperature as predictors of wound healing in diabetic foot ulcers (DFU).


Prospective, observational, time-bound study of 18 months, enrolling patients aged 18 to 60 years with uninfected DFU. The wound was assessed at baseline and after that, every week for 4 weeks according to the leg ulcer measurement tool (LUMT). Concurrently, wound surface pH and temperature were measured. The data were analyzed using descriptive statistics, and a P-value < .05 was considered statistically significant.


Fifty-four patients with DFU were included in the study with a mean age of 55 years and a male to female ratio of 1.57. The wound showed progressive improvement, a maximum mean LUMT score of 48.89 (± 2.81) at the initial evaluation and decreased progressively to the mean of 19.80 at week 4 (± 3.43), both of which were statistically significant (P-value < .001). Similarly, the median wound pH progressively reduced from 7.7 at baseline to 7.20 in the fourth week, and median wound temperature decreased from 90°F (32.22 °C) at baseline to 85°F (29.44 °C) in the fourth week, both of which were statistically significant (P-value < .001).


Progressive and significant change in wound pH to acidic and drop in wound surface temperature, both corresponding to improvement in the status of DFU, maximum at 4 weeks, make them valuable predictors of wound healing. However, further, more extensive studies are required to establish a concrete relationship.

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