Level of 25-hydroxyvitamin D and vitamin D receptor in diabetic foot ulcer and factor associated with diabetic foot ulcers #ActAgainstAmputation @ALPSlimb

Tang and coworkers present these data.

Bottom line:

  1. The study aimed to investigate the correlation between vitamin D deficiency and diabetic foot osteomyelitis (DFO) in patients with type 2 diabetes mellitus (T2DM) and diabetic foot ulcer (DFU).
  2. The levels of serum 25-hydroxyvitamin D [25(OH)VD] and vitamin D receptor (VDR) expression in wound margin tissues were found to be significantly lower in patients with DFU and DFO compared to those without DFU or healthy controls.
  3. Low levels of serum 25(OH)VD and decreased T-VDR expression were identified as independent risk factors for DFU and DFO. Serum 25(OH)VD and T-VDR were also found to be potentially valuable biomarkers for the diagnosis and prognosis of DFU and DFO.

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