Perhaps we need to treat wounds in the manner that our Mohs surgery colleagues treat lesions: debride back to clean margins. Obviously, we’ve discussed and written a great deal about appropriate technique in surgical debridement. However, as we’ve said for the longest time: we can’t manage what we can’t measure. Getting accurate bedside “theragnostics” to identify when we have margins that are ready to accept cell signaling from the matrix is when we need to stop. I think that this era is rapidly descending upon us.