This gene variant is associated with poor healing and amputation in diabetic foot ulcers. Promise for future targeting?

Congratulations to our SALSAmigo David Margolis and coworkers for this fascinating work. Might this be an avenue for detection and intervention?

NOS1AP genetic variation is associated with impaired healing of diabetic foot ulcers and diminished response to healing of circulating stem/progenitor cells.

It is unclear why many with diabetes develop foot ulcers (DFU) and why some do not heal. It could be associated with genetic variation. We have previously shown that variation is associated with lower extremity amputation in those with diabetes and that circulating stem progenitor cell concentration (SPC) is associated with impaired foot ulcer healing in those with diabetes. The goal of this study was to determine if NOS1AP variation is associated with impaired wound healing and with SPC mobilization in those with DFU. In longitudinal cohort study we demonstrate that NOS1AP variants rs16849113 and rs19649113 are associated with impaired wound healing and with SPC mobilization in those with DFU. We believe that further study of NOS1AP is merited and that it NOS1AP might be associated with a functional impairment. This article is protected by copyright. All rights reserved.

David G. Armstrong

Dedicated to amputation prevention, wound healing, diabetic foot, biotechnology and the intersection between medical devices and consumer electronics.


  • An hyperostose,a chain of reaction which begins with more and more proliferation, with each new hyperglycémie and less differentiation with a lack of SCCE/SCTE to scrap the last stratum corneum. we can help it happen on the hold body or just on both feet. while the wound is protected with a patch to maintain his own humidity.

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.