Survival and factors predicting mortality after major and minor lower-extremity amputations among patients with diabetes: a population-based study using health information systems – PubMed

The present study confirms the high mortality rates described in patients with diabetes after non-traumatic LEA. It shows differences between minor and major LEA in terms of mortality rates and related risk factors. The study highlights the role of depression as specific risk factor for death in pat …
— Read on pubmed.ncbi.nlm.nih.gov/32690575/

Mortality at one and four years remains high in this study of 1053 people.

Renal and cardiovascular disease, not unexpectedly, are driving factors.