The Epidemiology of Antibiotic-Related Adverse Events in the Treatment of Diabetic Foot Infections @DerBalgrist #ActAgainstAmputation @ALPSlimb

Our colleagues at The Balgrist have another excellent contribution to the literature.


  • Objective: Summarize frequent and severe AEs of antibiotic use in diabetic foot infections (DFIs) from global prospective trials and observational studies
  • Most frequent AEs: Gastrointestinal intolerances (5%-22%)
    • More common with prolonged oral beta-lactam or clindamycin, or higher dose of tetracyclines
  • Symptomatic colitis due to Clostridium difficile: Variable depending on antibiotic (0.5%-8%)
  • Serious AEs:
    • Hepatotoxicity: Beta-lactams (5%-17%), quinolones (3%)
    • Cytopenias: Linezolid (5%), beta-lactams (6%)
    • Nausea: Rifampicin
    • Renal failure: Cotrimoxazole
  • Skin rash: Rare, commonly associated with penicillins or cotrimoxazole
  • Costs: AEs from prolonged antibiotic use lead to longer hospitalization, additional monitoring care, and additional investigations
  • Prevention: Keep antibiotic treatment duration short and use the lowest clinically necessary dose

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